
Estrogen is a hormone in the body. It is made mostly in the ovaries, glands, and other organs in the body like the:
It plays a role in:
You are taking an anti-hormone treatment because your cancer can grow from, and is sensitive to, estrogen. Anti-hormone treatments can block estrogen from being used by cancer cells. They can also affect how estrogen is made in your body.
There are 3 main types of treatment that affect estrogen levels in your body:
Hormone treatments that effect estrogen levels are:
– Tamoxifen: Blocks cancer cells from being able to use estrogen to grow.
– Goserelin: Blocks a signal to the ovaries so estrogen can’t be made.
– Letrozole, Anastrazole, and Exemestane: Stops estrogen from being made.
– Fulvestrant: Blocks the effects of estrogen and lowers the number of estrogen receptors.
Radiation Therapy to the pelvis can damage or change how the ovaries work. This can lead to a loss of estrogen in your body and may result in permanent menopause (when a person stops getting their period). Radiation therapy to this area can also cause other side effects like tightening, thinning, and dryness of the vagina.
The ovaries are glands that make estrogen in your body. An oophorectomy (surgery to remove the ovaries) will cause there to be less estrogen in your body.
Bone, muscle, and joint discomfort is a common side effect of many anti-hormone medicines. You might feel this in your hands, knees, back, hips, or shoulders. If you ever think about stopping your hormone therapy because of these symptoms, talk to your healthcare team first.
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Hot flashes can make you feel extra hot or sweaty.
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You may notice changes to your mood as your estrogen levels change. You may be at higher risk for anxiety and depression.
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Estrogen loss may make it harder to remember small, everyday details.
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Loss of estrogen can cause a change to your sexuality (sexual feelings, thoughts, attraction toward others) or intimacy (being close with another person). These changes can affect your quality of life and relationships. This may not seem like a big deal, but it’s an important part of your well-being. Talking about these issues may feel hard, but your healthcare team can help.
You might notice:
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Changes to your vagina can happen as estrogen levels change. This can include dryness, discharge, thinning, or inflammation of the vaginal tissue.
Dryness
To moisturize to the vagina, talk to your pharmacist about how to use products like Repagyn® and Replens®. Before using an estrogen-based medicine talk to your Oncologist. For sexual purposes you can use water or silicone based lubricants (lube) that can be bought at the pharmacy, online, or in sex stores.
Vaginal Discharge
It is normal to have clear, yellow, or white discharge. You can use a pad or underwear liner if needed. If you have any bloody discharge tell your healthcare team.
Radiation Vaginal Changes
If you are getting radiation treatment that affects the vagina it may lead to vaginal dryness and thinning. Your radiation team will give you more information about how to manage these side effects.
Eating a balanced diet is one of the best things you can do for your health. You are in control of your food choices, and your food choices can affect how you feel.
Eating well and staying at a healthy weight will help you to build up your strength, have more energy, and feel better overall. It can also help to lower your risk of new cancers, heart disease, stroke, and diabetes.
Eat these foods as part of a balanced diet:
Refer to Canada’s Food Guide for more information on portions and food choices.
Natural health products include herbal remedies, vitamins or mineral supplements, homeopathic medicines, or traditional medicines.
Cancer treatments try to damage cancer cells while trying not to hurt healthy cells. Natural health products may change how your treatment works and targets cancer cells. They may even make side effects worse, or affect other health conditions. Information on natural health products during cancer treatment is always changing.
Tell your healthcare team if you are currently taking any natural health products. Also, talk to your healthcare team before starting any new natural health products.
Phytoestrogens are a type of plant hormone that mimics human estrogen. Some foods, natural health products, or personal care products (like lotion), may have phytoestrogens in them. These substances can act like estrogen in the body. In high amounts, phytoestrogens may alter how your cancer treatment works.
Soy products and flaxseed are foods high in phytoestrogens. Eating food sources of soy and flaxseed are safe when taken in moderation, as part of a varied diet. Do not take concentrated sources of these foods. If you would like to include soy products or ground flax in your diet, you can do so by having: :
Natural Health Products that have phytoestrogens in them should not be taken while you are on anti-hormone treatments.
Tell your healthcare team if you are taking, or planning to start, any natural health product(s).
Alcohol raises your risk of getting many cancers, such as breast cancer. If you drink, limit to no more than 1-2 standard drinks (12 ounces of beer, 5 ounces of wine, 1.5 ounces of spirits) per week. If you don’t drink, it is best not to start.
Smoking can affect your body’s ability to heal and process medicine. Smoking can also cause heart disease, lung disease, poor blood flow, ulcers, and other types of cancer. Even 1 or 2 cigarettes can be harmful. If you are interested in quitting smoking, please talk with your healthcare team or family doctor.
Weight gain can be a normal side effect of estrogen going down (5-10 pounds or 2.3-4.6 kilograms). Regular exercise and diet changes can help maintain and manage a healthy weight.
Exercise can help you have energy and stay strong during and after treatment. Any exercise is better than no exercise. Even a short walk each day can help. If you are not currently active, talk to your family physician before adding new exercises.
Exercise can help manage:
Examples of simple, low-impact activity:
Examples of muscle/bone strengthening activity:
If you need help getting started safely with exercise, talk to your family doctor about a referral to a physiotherapist.
As you age, you lose bone mass and density (how hard your bones are). In menopause you can lose 1% of your bone mineral density each year. This can put you at higher risk for osteoporosis (where bone cells are lost faster than the body can remake them).
To keep your bones healthy while on hormone treatment, you will need to take enough calcium and vitamin D. Refer to Osteoporosis Canada’s Calcium Calculator to learn more about food sources.
Visit the J. Wesley Graham Patient & Family Resource Centre for more information about cancer and supports. You can also scan or click the links below to access more information:
About This Resource
Author: Waterloo Wellington Regional Cancer Program
Revised: December 2025
Use this resource for your information only. It does not replace medical advice from your doctor or other healthcare professionals.
Email: [email protected]
Website: www.cancerwaterloowellington.ca